Document Detail

Type 2 diabetes and coronary heart disease: focus on myocardial infarction.
MedLine Citation:
PMID:  19192428     Owner:  NLM     Status:  MEDLINE    
Individuals with type 2 diabetes are more likely to experience a myocardial infarction and have worse outcomes compared with nondiabetic individuals. The underlying pathophysiology of the atherosclerotic process is accentuated but not significantly different in patients with type 2 diabetes. In addition, the prothrombotic state associated with diabetes may also contribute to the higher incidence of and worse prognosis after myocardial infarction. Difficulties of re-establishing vessel patency by thrombolytic or mechanical means due to diffuse coronary disease, altered vessel structure, and prothrombotic state can contribute to the high morbidity and mortality in these patients. The concurrent metabolic dysfunction contributes to impair compensatory mechanisms, which can increase infarct size and cause more impairment of left ventricular function. Aggressive medical therapy and careful modulation of glucose metabolism in the acute and follow-up phase of a myocardial infarction may favorably influence outcome.
Rodrigo M Lago; Richard W Nesto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current diabetes reports     Volume:  9     ISSN:  1539-0829     ISO Abbreviation:  Curr. Diab. Rep.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093791     Medline TA:  Curr Diab Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Lahey Clinic Medical Center, 41 Mall Road, Burlington, MA 01805, USA.
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MeSH Terms
Coronary Disease / epidemiology*,  surgery
Diabetes Mellitus, Type 2 / complications,  epidemiology,  physiopathology*
Diabetic Angiopathies / epidemiology*
Myocardial Infarction / epidemiology*
Myocardial Revascularization / statistics & numerical data
Risk Reduction Behavior
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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