Document Detail

Type 2 diabetes but not coronary atherosclerosis is an independent determinant of impaired mobility in angiographied coronary patients.
MedLine Citation:
PMID:  18829127     Owner:  NLM     Status:  MEDLINE    
AIMS: We aimed at determining the associations of type 2 diabetes (T2DM) and of angiographically determined coronary artery disease (CAD) with impaired mobility. METHODS: We enrolled 747 consecutive patients undergoing coronary angiography for the evaluation of stable CAD. Mobility was assessed by the standardized timed-up-and-go (TUG) test, a functional test of physical performance. RESULTS: Mobility was impaired (TUG time >10s) in 199 (26.6%) patients. The proportion of subjects with impaired mobility was higher among patients with T2DM than among non-diabetic individuals (40.2% vs. 22.0%; p<0.001), whereas it did not differ significantly between patients with significant coronary stenoses >or=50% and those without such lesions (p=0.802). Multivariate adjustment in logistic regression analyses confirmed that T2DM (adjusted odds ratio (OR)=2.05 [95% CI 1.35-3.11]; p=0.001) but not the presence of significant coronary stenoses (adjusted OR=0.81 [0.55-1.21]; p=0.306) was independently associated with impaired mobility. CONCLUSIONS: T2DM but not coronary atherosclerosis is an independent determinant of impaired mobility in the high risk population of angiographied coronary patients. Mobility enhancing exercise programs are needed for diabetic coronary patients.
Christoph H Saely; Thomas Dyballa; Alexander Vonbank; Magdalena Woess; Philipp Rein; Stefan Beer; Vlado Jankovic; Christian Boehnel; Stefan Aczel; Heinz Drexel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-01
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  82     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria.
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MeSH Terms
Coronary Angiography / methods*
Coronary Artery Disease / complications*,  radiography
Coronary Stenosis / complications,  radiography
Diabetes Mellitus, Type 2 / complications*,  radiography
Middle Aged
Regression Analysis

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