Document Detail


Type 2 diabetes-associated androgen alteration in patients with erectile dysfunction.
MedLine Citation:
PMID:  17877718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objective was to assess the pattern of type-2 diabetes-associated androgen alteration in patients with erectile dysfunction (ED). A total of 127 diabetic male patients with ED were enrolled in this study. Erectile function was assessed using the International Index of Erectile Function (IIEF). At the time of assessment, patients were also interviewed and assessed for socio-demographic and medical history that includes duration and severity of diabetes mellitus (DM). Patients underwent routine laboratory investigations, in addition to total testosterone (T), dehydroepiandrosterone sulphate (DHEA-S) and insulin assessment. The mean age +/- SD was 53.8 +/- 9.3 years. Of patients 25.2% (n = 32/127), 6.3% (n = 8/127) and 31.5% (n = 40/127) had low total T, low DHEA-S and hyperinsulinaemia respectively. There were significant association between the increase in age and body mass index and the presence of low T level. Of the patients 37.5% (n = 12/32) with low T level had glycosylated haemoglobin (HbA1c) >7% while, 22.1% (n = 21/95) of the patients with normal T level had HbA1c >7% (p < 0.05). There were significant associations between the number of patients with low level of total T or DHEA-S and poor control of DM. Patients with low T level were two times more likely (56.3%, n = 18/32) to have severe ED than patients with normal T level (27.4%, n = 26/95) (p < 0.01). There were significant differences between the mean levels of total T or DHEA-S and poor control of DM. No significant associations were detected between hyperinsulinaemia and the level of fasting blood sugar, duration of DM, metabolic control of DM or ED severity. Patients with low T level were three times as likely to have hyperinsulinaemia as those patients with normal T level (p < 0.05). The current study clearly demonstrated that there were significant associations between low level of total T or DHEA-S and poor control of DM.
Authors:
A I El-Sakka; H M Sayed; K A Tayeb
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Publication Detail:
Type:  Journal Article     Date:  2007-09-18
Journal Detail:
Title:  International journal of andrology     Volume:  31     ISSN:  1365-2605     ISO Abbreviation:  Int. J. Androl.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000141     Medline TA:  Int J Androl     Country:  England    
Other Details:
Languages:  eng     Pagination:  602-8     Citation Subset:  IM    
Affiliation:
Department of Urology, Suez Canal University, Ismailia, Egypt. aielsakka@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aging
Dehydroepiandrosterone Sulfate / blood*
Diabetes Mellitus, Type 2 / complications,  physiopathology*
Erectile Dysfunction / etiology,  physiopathology*
Humans
Insulin / blood*
Male
Testosterone / blood*
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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