Document Detail

Type 2 vaccine-derived poliovirus from patients with acute flaccid paralysis in china: current immunization strategy effectively prevented its sustained transmission.
MedLine Citation:
PMID:  21050127     Owner:  NLM     Status:  MEDLINE    
In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the administration of the initiating oral polio vaccine (OPV) dose, which is consistent with the rapid evolution rate of poliovirus genomes. The above-mentioned VDPVs have important implications in the global polio eradication initiative. Localized, limited, and transient circulation may be typical of OPVs; hence, independent VDPVs could be found because of the large population and excellent surveillance system, which permitted early detection and response, but sustained transmission was limited because of high population immunity.
Yong Zhang; Dongmei Yan; Shuangli Zhu; Ning Wen; Li Li; Haiyan Wang; Jianfeng Liu; Xufang Ye; Zhengrong Ding; Dongyan Wang; Hui Zhu; Li Chen; Xiaohui Hou; Hongqiu An; Xiaofeng Liang; Huiming Luo; Olen Kew; Wenbo Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-04
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  202     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2010-12-13     Revised Date:  2011-07-13    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1780-8     Citation Subset:  AIM; IM    
World Health Organization Western Pacific Regional Polio Reference Laboratory and State Key Laboratory for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY948201;  HM107832;  HM107833;  HM107834;  HM107835
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MeSH Terms
Child, Preschool
China / epidemiology
Cluster Analysis
Immunization / methods*
Molecular Epidemiology
Molecular Sequence Data
Point Mutation
Poliomyelitis / epidemiology*,  pathology,  prevention & control*,  virology
Poliovirus / classification*,  genetics,  immunology*,  isolation & purification
Poliovirus Vaccine, Oral / adverse effects*,  immunology*
RNA, Viral / genetics
Sequence Analysis, DNA
Sequence Homology
Reg. No./Substance:
0/Poliovirus Vaccine, Oral; 0/RNA, Viral
Comment In:
J Infect Dis. 2011 Jun;203(12):1875; author reply 1875-6   [PMID:  21606545 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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