| Type 2 Diabetes and hepatocellular carcinoma: A Case-control study in patients with chronic hepatitis B. | |
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MedLine Citation:
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PMID: 22052244 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Type 2 diabetes has been suggested as an independent risk factor for the development of hepatocellular carcinoma (HCC). However, the role of type 2 diabetes on the development of HCC in the presence of chronic hepatitis B (CHB) is still inconclusive. We conducted this hospital-based case-control study to evaluate the roles of type 2 diabetes in HCC development in patients with CHB. From January 2004 to December 2008, a total of 6275 eligible consecutive patients with chronic hepatitis B virus (HBV) infection were recruited. 1105 of them were patients with HBV-related HCC and 5,170 patients were CHB but without HCC. We used multivariate logistic regression models to investigate the association between type 2 diabetes and HCC risk. The prevalence of type 2 diabetes is higher among HCC patients without cirrhosis than among those with cirrhosis (12.1% vs. 6.7%, P=0.003). Type 2 diabetes was associated with a significantly high risk of HCC in female patients after adjusting for age, family history of HCC, city of residence, hepatitis B e antigen and cirrhosis with an odds ratio (95% confidence interval, CI) of 1.9 (1.1-3.4). Restricted analyses among female patients without cirrhosis indicated that type 2 diabetes was strongly associated with HCC risk with adjusted odds ratio (95%CI) of 5.6 (2.2-14.1). In conclusion, type 2 diabetes is independently associated with the increased risk of HCC in female CHB patients. Female CHB patients with type 2 diabetes are of a high HCC risk population and should be considered for HCC close surveillance program. © 2011 Wiley-Liss, Inc. |
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Authors:
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Qiang Li; Wen-Wen Li; Xia Yang; Wen-Bo Fan; Jin-Hong Yu; Shuang-Shuang Xie; Li Liu; Li-Xian Ma; Shi-Jun Chen; Naoya Kato |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: - ISSN: 1097-0215 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 UICC. |
Affiliation:
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Division of Liver Disease, Jinan Infectious Disease Hospital, Shandong University, Jinan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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