| Type 2 Diabetes does not worsen prognosis in hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 21501980 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Type 2 Diabetes (T2DM) is associated with liver inflammation and carcinogenesis. The prevalence of T2DM among patients with liver cirrhosis and hepatocellular carcinoma is increasing. However, the effect of T2DM on the natural history of hepatocellular carcinoma is not known. AIM: To examine the effect of T2DM on hepatocellular carcinoma (HCC) survival in treated and untreated disease. METHODS: Retrospective analysis was performed on HCC cases diagnosed during 2000-2005, and prospectively during 2006-August2007. Demographics, HCC staging, response to treatment, and survival were collected. A comparison was made between patients with T2DM and without T2DM. RESULTS: One hundred and thirty-five patients were recruited in total; 58 (43%) had T2DM. Seventy (37 diabetic) patients were treated with percutaneous radiological therapies, with 168 treatments given. Treatment was determined by AASLD guidelines and patient tolerance, there was no randomisation. There was no significant difference in survival between diabetic and nondiabetic patients. There was a nonsignificant trend towards greater survival in diabetic patients (overall median survival diabetics 21mths vs nondiabetics 5mths, P=0.355). CONCLUSIONS: T2DM does not negatively impact on the natural history of treated or untreated HCC. |
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Authors:
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J Howell; M Yiu; R Gibson; B Thomson; D Stella; A Gorelik; P J Prichard; A J Nicoll |
Publication Detail:
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Type: Journal Article Date: 2011-01-26 |
Journal Detail:
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Title: Clinics and research in hepatology and gastroenterology Volume: 35 ISSN: 2210-741X ISO Abbreviation: Clin Res Hepatol Gastroenterol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101553659 Medline TA: Clin Res Hepatol Gastroenterol Country: France |
Other Details:
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Languages: eng Pagination: 214-20 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Gastroenterology, Royal Melbourne Hospital, PO Box RMH, Vic. 3050, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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