| Type 2 Diabetes Mellitus: A Possible Surgically Reversible Intestinal Dysfunction. | |
| | |
MedLine Citation:
|
PMID: 22094369 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Type 2 diabetes mellitus (T2DM) is a global public health problem often associated with obesity. Bariatric surgery is effective for treating serious obesity, and techniques involving intestinal bypass have metabolic benefits, such as complete and early remission of T2DM. We present a literature review of the possible mechanisms of early normalization of glycemic homeostasis after bariatric surgery, including intestinal gluconeogenesis, increased antidiabetogenic signals from L cells located in the distal small intestine, and impaired secretion of diabetogenic signals in the upper part of the small intestine. Adding to these potential mechanisms, unknown factors that regulate insulin sensitivity may be involved and altered by bariatric surgery. This review discusses the various hypotheses about the mechanisms of glycemic control after bariatric surgery involving intestinal bypass. Further research is essential to better understand these mechanisms and to identify potential new mechanisms that might help in developing less invasive and safer alternatives for the treatment of T2DM and reveal novel pharmaceutical targets for glycemic control. |
| | |
Authors:
|
Priscila C Sala; Raquel S Torrinhas; Steven B Heymsfield; Dan L Waitzberg |
Related Documents
:
|
12744929 - Maternal diabetes mellitus is associated with altered deposition of fibrin-type fibrino... 12196479 - Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. 12793079 - Effect of the definition of hypopnea on apnea/hypopnea index. 22587909 - Early intervention with liraglutide improves glucose tolerance without affecting islet ... 8016559 - Mandibular premolar differentiation. 20634089 - High interleukin-12 production from stimulated peripheral blood mononuclear cells of ty... 9434319 - Effects of glycerol-1,2-dimethylsuccinate and propanediol-1,2-dimethylsuccinate on insu... 6987119 - Hagfish insulin: the discrepancy between binding affinity and biologic activity. 17329619 - Omentin plasma levels and gene expression are decreased in obesity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-18 |
Journal Detail:
|
Title: Obesity surgery Volume: - ISSN: 1708-0428 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Gastroenterology-Digestive Surgery Discipline (LIM 35), University of São Paulo-Medical School, Av. Dr. Arnaldo, 455, Cerqueira César, CEP: 01246-930, São Paulo, SP, Brazil, priscila_csala@hotmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Revision of Laparoscopic Adjustable Gastric Banding: Success or Failure?
Next Document: Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis.