| Type 1 diabetes: primary antigen/peptide/register/trimolecular complex. | |
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MedLine Citation:
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PMID: 22956469 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Type 1A diabetes (autoimmune) is now immunologically predictable in man, but preventable only in animal models. What triggers the development of autoimmunity in genetically susceptible individuals remains unknown. Studies of non-obese diabetic (NOD) mice reveal that interactions between T-cell receptors of diabetogenic T cell and an MHC class II loaded with an autoantigen are key determinates of the disease. With insulin as the primary target in the NOD mouse, likely man, and possibly the RT1-U rat models, therapeutic targeting of the components of these anti-insulin trimolecular complexes we believe provide a fulcrum for development of preventive therapy. In particular for the NOD mouse model, there is extensive evidence that the dominant insulin peptide driving disease initiation is insulin B chain amino acids 9-23 (SHLVEALYLVCGERG) recognized predominantly by germ-line sequences of a specific T-cell receptor Valpha (TRAV5D-4), and small molecules or monoclonal antibodies directed at this recognition complex can prevent diabetes. |
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Authors:
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Tomasz Sosinowski; George S Eisenbarth |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-6 |
Journal Detail:
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Title: Immunologic research Volume: - ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, 1775 Aurora Court, MS B-140, Aurora, CO, 80045, USA, Tomasz.sosinowski@ucdenver.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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