Document Detail


Type 1 diabetes: current concepts in epidemiology, pathophysiology, clinical care, and research.
MedLine Citation:
PMID:  23046732     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of beta cells, and lifelong dependency on exogenous insulin. Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed.
Authors:
Mary Joyce Gan; Anastasia Albanese-O'Neill; Michael J Haller
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current problems in pediatric and adolescent health care     Volume:  42     ISSN:  1538-3199     ISO Abbreviation:  Curr Probl Pediatr Adolesc Health Care     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134613     Medline TA:  Curr Probl Pediatr Adolesc Health Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Pediatrics, University of Florida, Gainesville, FL.
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