Document Detail


Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6.
MedLine Citation:
PMID:  7490073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative trait loci mapping was used to identify the chromosomal location of genes that contribute to increase the resistance to apoptosis induced in immature CD4+8+ thymocytes. An F2 intercross of the nonobese diabetic (NOD) mouse (displaying an apoptosis-resistance phenotype) and the C57BL/6 mouse (displaying a nonresistance phenotype) was phenotypically analyzed and genotyped for 32 murine microsatellite polymorphisms. Maximum likelihood methods identified a region on the distal part of chromosome 6 that is linked to dexamethazone-induced apoptosis (lod score = 3.46) and accounts for 14% of the phenotypic variation. This chromosomal region contains the diabetes susceptibility locus Idd6, suggesting that the apoptosis-resistance phenotype constitutes a pathogenesis factor in IDDM of NOD mice.
Authors:
C Penha-Gonçalves; K Leijon; L Persson; D Holmberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  28     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-03     Completed Date:  1996-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Affiliation:
Department for Cell and Molecular Biology, University of Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects,  genetics*
Cells, Cultured
Chromosome Mapping*
Dexamethasone / pharmacology*
Diabetes Mellitus, Type 1 / genetics*
Drug Resistance
Female
Male
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Phenotype
Thymus Gland / cytology
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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