Document Detail

Type 1 collagen marker of bone turnover, insulin-like growth factor, and leptin in dichorionic twins with discordant birth weight.
MedLine Citation:
PMID:  16940458     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the relationship between IGF-I-IGF binding protein (IGFBP)-1 and leptin levels with type 1 collagen markers of bone turnover in dichorionic twins with or without discordant birth weight of 20% or greater. METHODS: Maternal and cord bloods were collected from gestational age-matched dichorionic twins with (n = 16) or without (n = 16) discordant birth weight. The samples were assayed for cross-linked carboxyl terminal telopeptide (ICTP, a marker of bone resorption) and propeptide (PICP, a marker of bone formation) of type I collagen, leptin, IGF-I, and IGFBP-1 by RIA. RESULTS: The intrauterine growth-restricted (IUGR) twins of the discordant group had higher fetal ICTP (P < 0.001) and IGFBP-1 (P < 0.001) levels, whereas PICP (P < 0.001), IGF-I (P < 0.001), and leptin (P < 0.001) were lower than the cotwins with normal weight (AGA). In contrast, concentrations of IGF-I, IGFBP-1, ICTP, PICP, and leptin were comparable between concordant twin pairs. Leptin levels were positively correlated with PICP (r = 0.61; P < 0.001) and negatively with ICTP (r = -0.57; P < 0.001) in concordant and AGA twins but not in IUGR twins. In IUGR twins, IGF-I had positive association with PICP (r = 0.76; P < 0.001) and negative association with ICTP (r= -0.76; P < 0.001), whereas IGFBP-1 was negatively correlated with PICP levels (r = -0.65; P < 0.01). No such association was found in concordant and AGA twins. CONCLUSION: These data suggest that IUGR twins had high bone turnover, which is independent of maternal factors and perhaps may be due to altered IGF axis.
Rekha Bajoria; Suren R Sooranna; Ratna Chatterjee
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-08-29
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  91     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4696-701     Citation Subset:  AIM; IM    
Academic Unit of Obstetrics and Gynecology, St Mary's Hospital for Women and Children, Manchester, United Kingdom.
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MeSH Terms
Biological Markers
Birth Weight*
Bone Remodeling
Case-Control Studies
Collagen Type I / blood*
Fetal Development
Insulin-Like Growth Factor Binding Protein 1 / blood
Insulin-Like Growth Factor I / analysis*
Leptin / blood*
Peptide Fragments / blood
Procollagen / blood
Twins, Dizygotic / blood*,  metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/IGFBP1 protein, human; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Leptin; 0/Peptide Fragments; 0/Procollagen; 0/procollagen type I carboxy terminal peptide; 67763-96-6/Insulin-Like Growth Factor I

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