| Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics. | |
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MedLine Citation:
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PMID: 23197216 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Insulin, a crucial therapeutic agent for diabetes mellitus, has been rarely associated with hypersensitivity events. We present a 69-year-old type-2 diabetic patient with urticariform lesions on the sites of subcutaneous injection of insulin. The patient denied any known allergies, except for an unspecific cutaneous reaction after intramuscular penicillin administration in childhood. Prick tests revealed positive reactions to all tested human insulins and insulin analogues. Serum IgE levels were above normal range and RAST tests were positive for human, bovine and porcine insulins, as well as beta-lactams. Type 1 IgEmediated allergy to insulin analogues demands a prompt diagnosis and represents a significant therapeutic challenge in diabetic patients. |
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Authors:
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Pedro Andrade; Luísa Barros; Margarida Gonçalo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anais brasileiros de dermatologia Volume: 87 ISSN: 1806-4841 ISO Abbreviation: An Bras Dermatol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067662 Medline TA: An Bras Dermatol Country: Brazil |
Other Details:
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Languages: eng Pagination: 917-9 Citation Subset: IM |
Affiliation:
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Dermatology and Venereology Service, Teaching Hospitals of University of Coimbra, Coimbra, Portugal. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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