Document Detail


Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms.
MedLine Citation:
PMID:  23412845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several mycoplasma species have been shown to form biofilms that confer resistance to antimicrobials and which may affect the host immune system, thus making treatment and eradication of the pathogens difficult. The present study shows that the biofilms formed by two strains of the human pathogen Mycoplasma pneumoniae differ quantitatively and qualitatively. Compared with strain UAB PO1, strain M129 grows well but forms biofilms that are less robust, with towers that are less smooth at the margins. A polysaccharide containing N-acetylglucosamine is secreted by M129 into the culture medium but found in tight association with the cells of UAB PO1. The polysaccharide may have a role in biofilm formation, contributing to differences in virulence, chronicity and treatment outcome between strains of M. pneumoniae. The UAB PO1 genome was found to be that of a type 2 strain of M. pneumoniae, whereas M129 is type 1. Examination of other M. pneumoniae isolates suggests that the robustness of the biofilm correlates with the strain type.
Authors:
Warren L Simmons; James M Daubenspeck; John D Osborne; Mitchell F Balish; Ken B Waites; Kevin Dybvig
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-14
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  159     ISSN:  1465-2080     ISO Abbreviation:  Microbiology (Reading, Engl.)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-09-16     Revised Date:  2014-06-15    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  England    
Other Details:
Languages:  eng     Pagination:  737-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosamine / metabolism
Bacterial Adhesion
Biofilms / classification*,  growth & development
Colony Count, Microbial
Culture Media, Conditioned / chemistry
Humans
Mycoplasma pneumoniae / classification,  genetics,  growth & development*,  pathogenicity
Species Specificity
Grant Support
ID/Acronym/Agency:
5UL1 RR025777-03/RR/NCRR NIH HHS; AI63909/AI/NIAID NIH HHS; AI64848/AI/NIAID NIH HHS; AI93750/AI/NIAID NIH HHS; R01 AI063909/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media, Conditioned; V956696549/Acetylglucosamine
Comments/Corrections

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