| The Ty1 LTR-retrotransposon population in Saccharomyces cerevisiae genome: dynamics and sequence variations during mobility. | |
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MedLine Citation:
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PMID: 21272231 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transposable element (TE) evolution in genomes has mostly been deduced from comparative genome analyses. TEs often account for a large proportion of the eukaryotic nuclear genome (up to 50%, depending on the species). Among the many existing genomic copies, only a small fraction may contribute to the mobility of a TE family. We have identified here, using a genetic screening procedure to trap Ty1 LTR-retrotransposon insertions in Saccharomyces cerevisiae, which among the population of resident Ty1 copies are responsible for Ty1 mobility. Although the newly inserted Ty1 copies resulting from a single round of transposition were found to originate from a limited subset of Ty1 resident copies, they showed a high degree of diversity at the nucleotide level, mainly due to the reverse transcription-mediated recombination. In this process, highly expressed and strikingly non-autonomous mutant Ty1 were found to be the most frequently used resident copies, which suggests that non-autonomous elements play a key role in the dynamics of the Ty1 family. |
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Authors:
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Claudine Bleykasten-Grosshans; Paul P Jung; Emilie S Fritsch; Serge Potier; Jacky de Montigny; Jean-Luc Souciet |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-27 |
Journal Detail:
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Title: FEMS yeast research Volume: - ISSN: 1567-1364 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101085384 Medline TA: FEMS Yeast Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
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Laboratoire de Génétique Moléculaire, Génomique et Microbiologie UMR7156 (Université de Strasbourg and CNRS), 67083 Strasbourg, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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