Document Detail


Two years' experience with an enhanced chemiluminescent assay for neonatal blood spot TSH.
MedLine Citation:
PMID:  9247672     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a blood spot assay for thyroid stimulating hormone (TSH) based on the Amerlite TSH-30 serum assay for use in the Welsh neonatal hypothyroid screening programme. A total of 67,656 infants were screened in 1994 and 1995, and 28 cases of primary hypothyroidism were detected, giving a prevalence of one in 2416. The method is sensitive and rapid, results being available within 3 h of receipt of samples. The assay enables much faster detection of primary hypothyroidism than was previously possible, and therefore contributes to earlier treatment of affected infants.
Authors:
R John; R Henley; N Oversby
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  34 ( Pt 4)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-15     Completed Date:  1997-09-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  396-9     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry, University Hospital of Wales, Healthcare NHS Trust, Heath Park, Cardiff, UK.
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MeSH Terms
Descriptor/Qualifier:
Chemiluminescent Measurements
Congenital Hypothyroidism
Female
Humans
Hypothyroidism / diagnosis*
Immunoenzyme Techniques*
Infant, Newborn
Male
Mass Screening
Quality Control
Reagent Kits, Diagnostic
Sensitivity and Specificity
Thyrotropin / blood*
Wales
Chemical
Reg. No./Substance:
0/Reagent Kits, Diagnostic; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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