Document Detail

Two-year outcomes for infants with low cord pH at birth.
MedLine Citation:
PMID:  24090442     Owner:  NLM     Status:  Publisher    
Abstract Objective: To determine the long-term outcome of infants born with cord pH ≤7.0 and no clinical evidence of asphyxia at birth. Design: Setting: Tertiary Referral Centre. A prospective matched cohort study was conducted. 51 term infants were recruited following singleton birth with venous cord pH ≤7.0.For each recruited baby a healthy baby with normal cord pH >7.20 was recruited matched for gestation, gender and mode of delivery. Ages and Stages Questionnaires (ASQ)(TM) and Health Screening Questionnaires (HSQ) were sent out at 24 months of age. Two independent assessors, blinded to the case assignment, reviewed intrapartum and neonatal events to look for clinical evidence of birth asphyxia among the cases. Result: From 102 infants recruited, 62 questionnaires (24 cases, 38 controls) were returned. 20 matched pairs with no clinical evidence of birth asphyxia were available for analysis. The groups were similar except in terms of birth weight; the pH<7.0 group had mean birth weight 584g lower than controls (p=0.005). The ASQ motor scores were lower in children born with low cord pH (p=0.019), however, once adjusted for birth weight, the difference was not significant (p=0.289). Conclusion: It is unlikely that abnormal cord pH in otherwise healthy neonates leads to a substantially increased risk of abnormal neurodevelopmental outcome or severe health problems by 2 years of age.
Salma I Kayani; Maw Joo Tan; Nigel J Shaw; Christopher Dewhurst; Andrew Titman; Gillian Lancaster; Zarko Alfirevic
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-4
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Consultant Obstetrician & Gynaecologist, Advanced Minimal Access Surgeon, Kent, United Kingdom.
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