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Two-year neonatal outcome following PPROM prior to 25weeks with a prolonged period of oligohydramnios.
MedLine Citation:
PMID:  22682720     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Improved neonatal survival data have been reported following early preterm prelabour rupture of membranes (PPROM) prior to 25weeks gestation with a prolonged latency to delivery and persistent oligohydramnios. However, data regarding long-term respiratory and neurological morbidity are lacking. AIMS: To evaluate the respiratory and neurological outcome data at two years of age in a cohort of infants born following PPROM prior to 25weeks with a prolonged latency (14days) to delivery and compare the data to an aged matched group of infants. METHODS: Retrospective case note analysis over a 43-month period at Saint Luc University Hospital, Brussels. RESULTS: 15 surviving infants born following PPROM were matched to a group of 30 control infants. Although there was no significant difference in the incidence of BPD between the groups (33% vs 27%, p=0.24), the length of hospitalisation, duration of respiratory support and number of hospital readmissions for respiratory indications were all significantly higher for infants born following a prolonged period of oligohydramnios. There were no major anomalies on cranial ultrasound in the PPROM group and Baileys developmental assessment at 20-24months corrected gestational age showed no difference between the two groups (Mental development index 93.9 vs 94.4 and Psychomotor development index 95.5 vs 95.8 respectively p = ns). CONCLUSION: Neurodevelopmental outcome appears encouraging in this cohort although these infants are at high risk of prolonged initial hospitalisation and significant respiratory morbidity in the first two-years of life.
Authors:
O Williams; B Michel; G Hutchings; C Debauche; C Hubinont
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neonatology, Cliniques Universitaires Saint Luc, Catholic University of Louvain, Brussels, Belgium.
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