Document Detail


Two year maintenance treatment of duodenal ulcer disease with ranitidine 150 mg: a prospective multicentre randomised study. GEMUD (Groupe d'Etude de la Maladie Ulcéreuse Duodénale).
MedLine Citation:
PMID:  8282251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maintenance treatment of duodenal ulcer (DU) with ranitidine 150 mg/day was compared with placebo in a two year prospective multicentre randomised study. Three hundred and ninety nine patients were included (mean age: 44.7 years, M/F ratio = 2.47/1; 37.6% of smokers) in placebo (n = 202) and ranitidine (n = 197) groups. Efficacy was assessed by the length of time to the first ulcer pain attack (with or without endoscopic confirmation) or DU complication. One hundred and fourteen patients of 399 (28.6%) had incomplete follow up. Actuarial survival curves of patients without ulcer pain (26 and 53% at two years in placebo and ranitidine groups, respectively) were significantly different (p < 0.0001). Endoscopies were performed depending on physicians' decision (mainly where there was severe pain or complication). Patients without relapses from endoscopy were more frequent in the ranitidine group (83%) than in the placebo group (47%, p < 0.0001). A greater incidence of complications, mainly bleeding, was also seen in the placebo group (13 complications v two in the ranitidine group, p < 0.002). No factor predicting DU relapse was identified. No important side effect was encountered. Ranitidine 150 mg/day is effective and well tolerated in preventing ulcer pain attacks and DU complications for up to two years.
Authors:
P Ruszniewski; A Slama; M Pappo; M Mignon
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Gut     Volume:  34     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-17     Completed Date:  1994-02-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1662-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Gastroenterology, Hôpital Beaujon, Clichy, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Double-Blind Method
Duodenal Ulcer / complications,  prevention & control*
Female
Humans
Male
Pain / prevention & control
Patient Compliance
Peptic Ulcer Hemorrhage
Prospective Studies
Ranitidine / therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
66357-35-5/Ranitidine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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