Document Detail


Two-year follow-up study of a patient with Parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei: case report.
MedLine Citation:
PMID:  7501119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed co-grafts of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during "off" periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.
Authors:
I Date; S Asari; T Ohmoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  37     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-8; discussion 518-9     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, Okayama University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living / classification
Adrenal Medulla / pathology,  transplantation*
Adult
Caudate Nucleus / pathology,  physiopathology,  surgery*
Female
Humans
Intercostal Nerves / pathology,  transplantation*
Motor Skills / physiology
Nerve Regeneration / physiology
Neurologic Examination*
Parkinson Disease / pathology,  physiopathology,  surgery*
Postoperative Complications / physiopathology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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