| Two-year follow-up study of a patient with Parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei: case report. | |
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MedLine Citation:
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PMID: 7501119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed co-grafts of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during "off" periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term. |
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Authors:
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I Date; S Asari; T Ohmoto |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurosurgery Volume: 37 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1996-01-18 Completed Date: 1996-01-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 515-8; discussion 518-9 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, Okayama University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living
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classification Adrenal Medulla / pathology, transplantation* Adult Caudate Nucleus / pathology, physiopathology, surgery* Female Humans Intercostal Nerves / pathology, transplantation* Motor Skills / physiology Nerve Regeneration / physiology Neurologic Examination* Parkinson Disease / pathology, physiopathology, surgery* Postoperative Complications / physiopathology Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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