| Two-year follow-up of a prospective study of circulating regulatory T cells in renal transplant patients. | |
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MedLine Citation:
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PMID: 19744094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD4(+)CD25(high)FOXP3(+) regulatory T cells (Tregs) are involved in alloreactivity and may be associated with protection from rejection. Their quantification in peripheral blood could guide clinicians in the management of renal transplant patients. Thus, we prospectively monitored the levels and in vitro suppression of circulating Tregs in 33 renal transplant patients from deceased donors within the first two yr of transplantation. Patients received maintenance immunosuppression with tacrolimus, mofetil mycophenolate and prednisolone. Results showed that peripheral blood Tregs were significantly lower six months after transplantation and recovered to almost basal levels at first post-transplant year. The number of circulating Tregs increased significantly over basal levels afterwards. The decrease in circulating Tregs at six months may be explained by the high load of tacrolimus, as demonstrated by the inverse correlation between the blood concentration of Tregs and tacrolimus. Likewise, nine patients treated with anti-CD25 antibodies showed higher numbers of Tregs at six months than those that did not, although differences were not observed later. In conclusion, circulating Tregs decrease in the first six months but recover thereafter up to two yr after kidney transplantation. Such a decrease is favored by high levels of tacrolimus but not by induction protocols with anti-CD25. |
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Authors:
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David San Segundo; Gema Fernández-Fresnedo; Juan C Ruiz; Emilio Rodrigo; María J Benito; Manuel Arias; Marcos López-Hoyos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-11 |
Journal Detail:
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Title: Clinical transplantation Volume: 24 ISSN: 1399-0012 ISO Abbreviation: Clin Transplant Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-21 Revised Date: 2010-11-10 |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 386-93 Citation Subset: IM |
Affiliation:
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Immunology, Hospital Universitario Marques de Valdecilla-IFIMAV, 39008 Santander, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood* Female Follow-Up Studies Humans Immunosuppressive Agents / therapeutic use Kidney Transplantation / immunology* Male Middle Aged Prognosis Prospective Studies T-Lymphocytes, Regulatory / immunology* Time Factors Transplantation Immunology Transplantation Tolerance / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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