Document Detail

Two-year follow-up of infants enrolled in a randomized trial of surfactant replacement therapy for prevention of neonatal respiratory distress syndrome.
MedLine Citation:
PMID:  2459655     Owner:  NLM     Status:  MEDLINE    
A randomized clinical trial of the use of bovine surfactant for the prevention of neonatal respiratory distress syndrome was completed at our Institution in 1984 (Pediatrics 1985;76:145-153). All infants entering the trial were enrolled in our follow-up clinic and seen at regular intervals for assessment of growth and development, neurologic and sensory status, and incidence of respiratory disease and allergic conditions. Infants have now been followed-up for at least 2 years. Of those infants for whom follow-up is complete, two of 32 (6.3%) surfactant-treated infants died, five (15.6%) had major neuro-developmental handicaps, and five had minor neurodevelopmental handicaps. In the control group, eight of 33 (24%) infants died, whereas only two (6.1%) survived with major neurodevelopmental handicaps, and four (12.1%) were left with minor handicaps. Except for an increased neonatal death rate in the control group, other differences were not statistically significant. The groups were also comparable in terms of the incidence of late respiratory or allergic disease as assessed by history. Treatment with bovine surfactant at birth of premature infants at high risk for respiratory distress syndrome appears to be safe and of short-term benefit, although no decrease in neurodevelopmental handicap at 2 years' follow-up can be demonstrated.
M S Dunn; A T Shennan; E M Hoskins; K Lennox; G Enhorning
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatrics     Volume:  82     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-03     Completed Date:  1988-11-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-7     Citation Subset:  AIM; IM    
Regional Perinatal Unit, Women's College Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Clinical Trials as Topic
Developmental Disabilities / etiology
Follow-Up Studies
Infant, Newborn
Pulmonary Surfactants / therapeutic use*
Random Allocation
Respiratory Distress Syndrome, Newborn / complications,  prevention & control*
Retinopathy of Prematurity / etiology
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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