| Two-year follow-up of the Genous™ endothelial progenitor cell capturing stent versus the Taxus Liberté stent in patients with de novo coronary artery lesions with a high-risk of restenosis: A randomized, single-center, pilot study. | |
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MedLine Citation:
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PMID: 21542109 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: In the prospective randomized TRIAS pilot study, the bio-engineered Genous™ endothelial progenitor cell capturing stent was compared with the Taxus Liberté(TM) -SR paclitaxel-eluting stent. At 1 year, a statistically non-significant difference in the rates of target vessel failure (cardiac death, myocardial infarction, or target vessel revascularization) was observed. We have evaluated the safety and efficacy up to 2 years. METHODS: A total of 193 patients with de novo coronary artery lesions carrying a high risk of restenosis were randomized to a Genous stent versus a Taxus stent. Dual antiplatelet therapy was prescribed for ≥ 1 month after Genous stent implantation and for ≥ 6 months after a Taxus stent. RESULTS: Between 1 and 2 years, patients treated with the Genous stent tended to have fewer episodes of target lesion revascularization (2.0% versus 5.3%), but nearly similar rates of cardiac death (1.0% versus 0%), myocardial infarction (0% versus 1.1%) and stent thrombosis (0% versus 1.1%) when compared with the Taxus stent. As a result, at 2-year follow-up treatment with the Genous stent compared with the Taxus stent resulted in a non-significant difference in target vessel failure (TVR) (20.4% versus 15.8%; risk difference 4.6%, 95%CI -6.2% - 15.5%). No stent thrombosis was observed in the Genous group compared to 5 cases (in 4 patients) in the Taxus group, resulting in a difference as compared with the Taxus stent (risk difference -4.2%; 95%CI -8.2% - -0.2%). CONCLUSIONS: In the TRIAS pilot study, treatment of coronary artery lesions carrying a high risk of restenosis with the Genous compared with the Taxus stent resulted in a non-significant difference of TVR at 2-year follow-up, with convergence of the Kaplan-Meier curves between 1 and 2 years. Stent thrombosis was only observed after Taxus stent implantation © 2011 Wiley-Liss, Inc. |
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Authors:
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Marcel Am Beijk; Margo Klomp; Nan van Geloven; Karel T Koch; José Ps Henriques; Jan Baan; Marije M Vis; Jan Gp Tijssen; Jan J Piekmd; Robbert J de Winter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: - ISSN: 1522-726X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Cardiology, Academic Medical Center - University of Amsterdam, the Netherlands. m.a.beijk@amc.uva.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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