Document Detail

Two-year follow-up of agoraphobics after exposure and imipramine.
MedLine Citation:
PMID:  6367875     Owner:  NLM     Status:  MEDLINE    
Forty-five agoraphobic out-patients were randomly assigned to treatment with imipramine or placebo, and also to brief therapist-aided exposure or relaxation. All patients did systematic self-exposure homework and recorded this in a diary. Forty of these patients were followed-up two years later with self-ratings and ratings by interviewers blind to their treatment conditions. About two-thirds of the patients remained improved or much improved in their phobias, with no significant difference between any of the four treatment conditions. Spontaneous panics also remained improved. The absence of an imipramine effect may reflect the lack of initial dysphoria (anxiety-depression) in this sample compared with other studies where drug-effects have been found. The post-treatment superiority (evident at week 28) of patients who had therapist-aided exposure was no longer present at the two-year follow-up; the others had caught up, presumably because of their self-exposure homework.
S D Cohen; W Monteiro; I M Marks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  144     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-24     Completed Date:  1984-05-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  IM    
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MeSH Terms
Agoraphobia / drug therapy,  therapy*
Behavior Therapy*
Follow-Up Studies
Imipramine / therapeutic use*
Phobic Disorders / therapy*
Relaxation Therapy
Self Care
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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