Document Detail

Two-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database.
MedLine Citation:
PMID:  20079124     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In response to the increasing concern with the safety of the drug-eluting stent (DES), the present study aimed to evaluate the long-term safety and efficacy of DES used for a Chinese patient population. METHODS: All patients, who underwent an index elective percutaneous coronary intervention with an implantation of either DES or bare-metal stent (BMS) in a single institution from April 2004 to December 2006, were included in the analysis. A propensity-score matching technique was applied to adjust and to minimize the impact of confounding factors. RESULTS: Overall, there were 1465 patients (20.2%) who had undergone an implantation of only BMS, and 5769 patients (79.8%) of only DES. The propensity-score matching technique set up 1321 pairs of patients for analysis. There were no significant differences between the rates of stent thrombosis (definite and probable) of the two groups (1.06% vs 1.21%, P = 0.8580). Although rates of mortality and myocardial infarction (MI) during the 2-year follow-up period had not differed significantly, rates of death/MI (3.0% vs 4.5%, P = 0.0263), target-lesion revascularization (TLR, 3.2% vs 8.5, P = 0.0001), target-vessel revascularization (TVR, 5.8% vs 9.5%, P < 0.0001) and any revascularization (10.0% vs 13.3%, P = 0.0066) were significantly lower for the DES group than for the BMS group. Among the patients in whom devices were implanted for off-label indications, the propensity-score matched rates of stent thrombosis, mortality, MI, and death/MI were not significantly different, while rates of TLR, TVR and any revascularization were significantly lower for the DES group than for the BMS group. CONCLUSIONS: During the 2 years of follow-up post stenting, DES use is associated with lower rates of death/MI, TLR, TVR and any revascularization, compared with BMS, in propensity-score matched Chinese patient populations. In the setting of off-label usage, DES use is also associated with similar advantages.
Run-lin Gao; Bo Xu; Ji-lin Chen; Yue-jin Yang; Shu-bin Qiao; Yang Wang; Ke-fei Dou; Xue-wen Qin; Min Yao; Hai-bo Liu; Yong-jian Wu; Jin-qing Yuan; Jue Chen; Shi-jie You; Jun Dai; Wei-hua Ma; Wei Li
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  122     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  2261-7     Citation Subset:  IM    
Department of Cardiology, Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary* / mortality
Databases, Factual
Drug-Eluting Stents* / adverse effects
Follow-Up Studies
Middle Aged
Myocardial Infarction / mortality
Stents* / adverse effects

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