Document Detail

Two-year clinical outcomes after paclitaxel-eluting stent or brachytherapy treatment for bare metal stent restenosis: the TAXUS V ISR trial.
MedLine Citation:
PMID:  18556716     Owner:  NLM     Status:  MEDLINE    
AIMS: This study sought to investigate the 2-year outcomes of patients treated with the paclitaxel-eluting TAXUS((R)) stent (PES) or vascular brachytherapy (VBT), the previous 'gold standard therapy', for bare metal stent in-stent restenosis (ISR). METHODS AND RESULTS: In the TAXUS V-ISR trial, 396 patients with bare metal stent ISR referred for percutaneous coronary intervention were prospectively randomized to either PES or beta source VBT. The present analysis reports 24-month clinical outcomes from that study. Between 9 and 24 months, ischaemia-driven target lesion revascularization tended to be required less frequently with assignment to PES compared to VBT (5.3 vs. 10.3%, P = .07). As a result, ischaemia-driven target lesion revascularization at 24 months was significantly reduced with PES compared with VBT (10.1 vs. 21.6%, P = 0.003), as was ischaemia-driven target vessel revascularization (18.1 vs. 27.5%, P = .03). There were no significant differences between the two groups with regard to death, myocardial infarction, or target vessel thrombosis either between 12 and 24 months, or cumulative to 24 months. CONCLUSION: Freedom from clinical restenosis at 2 years is significantly enhanced after PES placement compared with VBT for bare metal stent ISR, with similar rates of death, myocardial infarction, and target vessel thrombosis.
Stephen G Ellis; Charles D O'Shaughnessy; Steven L Martin; Kenneth Kent; Thomas McGarry; Mark A Turco; Dean J Kereiakes; Jeffrey J Popma; Mark Friedman; Joerg Koglin; Gregg W Stone;
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-06-13
Journal Detail:
Title:  European heart journal     Volume:  29     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1625-34     Citation Subset:  IM    
Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, F25, Cleveland, OH 44195, USA.
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MeSH Terms
Coronary Restenosis / mortality,  therapy*
Drug-Eluting Stents*
Follow-Up Studies
Middle Aged
Myocardial Infarction / etiology,  mortality
Paclitaxel / administration & dosage*
Risk Factors
Treatment Outcome
Tubulin Modulators / administration & dosage*
Reg. No./Substance:
0/Tubulin Modulators; 33069-62-4/Paclitaxel
Comment In:
Eur Heart J. 2008 Jul;29(13):1595-6   [PMID:  18556717 ]

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