Document Detail

Two-year clinical outcome with drug-eluting stents versus bare-metal stents in a real-world registry of unprotected left main coronary artery stenosis from the Italian Society of Invasive Cardiology.
MedLine Citation:
PMID:  19026296     Owner:  NLM     Status:  MEDLINE    
Data are limited about the relative efficacy of drug-eluting stents (DESs) versus bare-metal stents (BMSs) for the treatment of unprotected left main coronary artery (ULMCA) stenosis. The survey promoted by the Italian Society of Invasive Cardiology on ULMCA stenosis was an observational study involving 19 high-volume Italian centers of patients with ULMCA stenosis treated using percutaneous coronary intervention (PCI). From January 2002 to December 2006, of 1,453 patients identified with ULMCA stenosis treated with PCI, 1,111 were treated with DESs and 342 were treated with BMSs. During a 2-year follow-up, risk-adjusted survival free from cardiac death was significantly higher in patients treated with DESs than in those treated with BMSs. The propensity-adjusted hazard ratio for risk of 2-year cardiac mortality after DES versus BMS implantation was 0.49 (95% confidence interval 0.32 to 0.77). The benefit of DESs in reducing cardiac mortality was obtained in the period from 3 to 6 months and maintained up to 2 years. In conclusion, for patients with ULMCA stenosis undergoing PCI, DES implantation was associated with higher adjusted rates of 2-year survival free from cardiac death. The benefit of DESs in reducing cardiac mortality was obtained in the period in which clinical manifestations of restenosis usually peak.
Tullio Palmerini; Antonio Marzocchi; Corrado Tamburino; Imad Sheiban; Massimo Margheri; Giuseppe Vecchi; Giuseppe Sangiorgi; Andrea Santarelli; Antonio Bartorelli; Carlo Briguori; Luigi Vignali; Francesco Di Pede; Angelo Ramondo; Luigi Inglese; Marco De Carlo; Leonardo Bolognese; Alberto Benassi; Cataldo Palmieri; Vincenzo Filippone; Diego Sangiorgi; Stefano De Servi
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-09-11
Journal Detail:
Title:  The American journal of cardiology     Volume:  102     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2008-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1463-8     Citation Subset:  AIM; IM    
Istituto di Cardiologia, Policlinico S Orsola, Università di Bologna, Bologna, Italy.
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MeSH Terms
Aged, 80 and over
Coronary Stenosis / mortality,  surgery*,  therapy
Drug-Eluting Stents*
Health Surveys
Middle Aged
Retrospective Studies
Risk Factors
Severity of Illness Index
Time Factors
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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