Document Detail


Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries.
MedLine Citation:
PMID:  11492966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia.
Authors:
M Shirai; A Shimouchi; S Ikeda; H Oya; K Y Min; A T Kawaguchi; H Mori; I Ninomiya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  51     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-08     Completed Date:  2001-10-25     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Affiliation:
National Cardiovascular Center Research Institute, Osaka, 565-8565 Japan. mshiraim@res.ncvc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anoxia / physiopathology*
Male
Nitric Oxide / pharmacology*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Pulmonary Artery / physiology*
Rats
Rats, Sprague-Dawley
Time Factors
Vascular Resistance / physiology*
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase

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