Document Detail


Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.
MedLine Citation:
PMID:  11146627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asymmetric partitioning of cell-fate determinants during development requires coordinating the positioning of these determinants with orientation of the mitotic spindle. In the Drosophila peripheral nervous system, sensory organ progenitor cells (SOPs) undergo several rounds of division to produce five cells that give rise to a complete sensory organ. Here we have observed the asymmetric divisions that give rise to these cells in the developing pupae using green fluorescent protein fusion proteins. We find that spindle orientation and determinant localization are tightly coordinated at each division. Furthermore, we find that two types of asymmetric divisions exist within the sensory organ precursor cell lineage: the anterior-posterior pI cell-type division, where the spindle remains symmetric throughout mitosis, and the strikingly neuroblast-like apical-basal division of the pIIb cell, where the spindle exhibits a strong asymmetry at anaphase. In both these divisions, the spindle reorientates to position itself perpendicular to the region of the cortex containing the determinant. On the basis of these observations, we propose that two distinct mechanisms for controlling asymmetric cell divisions occur within the same lineage in the developing peripheral nervous system in Drosophila.
Authors:
F Roegiers; S Younger-Shepherd; L Y Jan; Y N Jan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature cell biology     Volume:  3     ISSN:  1465-7392     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-08     Revised Date:  2008-10-15    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  58-67     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, California 94143-0725, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / genetics,  metabolism
Cell Cycle Proteins / genetics,  metabolism
Cell Division / genetics*
Cell Lineage / genetics*
Cell Polarity / genetics
Cytoskeletal Proteins / genetics,  metabolism
Drosophila / cytology,  growth & development*,  metabolism
Drosophila Proteins*
Frizzled Receptors
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Indicators and Reagents / analysis
Interphase / genetics
Juvenile Hormones / genetics,  metabolism
Luminescent Proteins / analysis
Membrane Proteins / genetics,  metabolism
Mitotic Spindle Apparatus / genetics,  metabolism
Neurons, Afferent / cytology,  metabolism*
Neuropeptides
Pupa / cytology,  growth & development,  metabolism
Receptors, G-Protein-Coupled
Sense Organs / cytology,  growth & development*,  metabolism
Stem Cells / cytology,  metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Cytoskeletal Proteins; 0/Drosophila Proteins; 0/Frizzled Receptors; 0/Indicators and Reagents; 0/Juvenile Hormones; 0/Luminescent Proteins; 0/Membrane Proteins; 0/Mira protein, Drosophila; 0/Neuropeptides; 0/Receptors, G-Protein-Coupled; 0/fz protein, Drosophila; 0/insc protein, Drosophila; 0/numb protein, Drosophila; 0/partner of Numb protein, Drosophila; 147336-22-9/Green Fluorescent Proteins

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