Document Detail

Two- or three-dimensional ultrasonography: which is the best predictor of pulmonary hypoplasia?
MedLine Citation:
PMID:  20582919     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of our study is to compare the three-dimensional (3D) ultrasound fetal lung volume measurements with two-dimensional (2D) ultrasound biometric parameters in predicting pulmonary hypoplasia (PH).
METHODS: From June 2006 to November 2008, we identified 35 fetuses at high risk for developing PH, including premature preterm rupture of membranes (17), fetal skeletal malformations (7), hydrothorax (7), and bilateral renal dysplasia (4). 3D lung volumes adjusted for gestational age (GA) or estimated fetal weight (EFW), thoracic circumference adjusted for GA or femur length, thoracic/abdominal circumference ratio, and thoracic/heart area ratio were measured.
RESULTS: Three infants were excluded because no clinical or histological information regarding lung hypoplasia was available. Of the 32 remaining infants, 13 (41%) were diagnosed with PH at postmortem examination or by clinical and radiological examination. 3D lung volume measurements had a better diagnostic accuracy for predicting PH either when adjusted for GA [sensitivity, 12/13 (92%); specificity, 16/19 (84%); positive predictive value 12/15 (80%); negative predictive value, 16/17(94%)] or EFW [sensitivity, 11/13 (85%); specificity, 18/19 (94%); positive predictive value 11/12(92%); negative predictive value, 18/20(90%)] compared to the 2D biometric measurement.
CONCLUSION: 3D lung volume measurements seem to be useful in the prenatal prediction of PH.
Patrizia Vergani; Marianna Andreani; Massimiliano Greco; Giuliano Farina; Tiziana Fedeli; Serena Cuttin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  834-8     Citation Subset:  IM    
Copyright Information:
(c) 2010 John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy.
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MeSH Terms
Fetal Diseases / ultrasonography*
Fetal Organ Maturity
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional*
Infant, Newborn
Lung / abnormalities,  ultrasonography*
Lung Volume Measurements / methods
Odds Ratio
Predictive Value of Tests
Ultrasonography, Prenatal / methods*

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