Document Detail

Two themes on the assembly of the Drosophila eye.
MedLine Citation:
PMID:  20959164     Owner:  NLM     Status:  MEDLINE    
Cells are sequentially recruited during formation of the Drosophila compound eye. A few simple rules are reiteratively utilized to control successive steps of eye assembly. Two themes emerge: the interplay between cell signaling and competence determines diversity of cell types and selective cell adhesion determines spatial patterns of cells. Cell signaling through competence creates signaling relays, which sequentially trigger differentiation of all cell types. Selective cell adhesion, on the other hand, provides forces to drive cells into energy-favored spatial configurations. Organ formation is nevertheless a complex process. The complexity lies in the spatial, temporal, and quantitative precision of gene expression. Many challenging questions remain.
Sujin Bao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current topics in developmental biology     Volume:  93     ISSN:  1557-8933     ISO Abbreviation:  Curr. Top. Dev. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-20     Completed Date:  2011-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0163114     Medline TA:  Curr Top Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-127     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Pediatrics, Mount Sinai School of Medicine, New York, USA.
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MeSH Terms
Cell Adhesion
Cell Differentiation
Cytoskeleton / metabolism
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster* / anatomy & histology,  embryology
Eye Proteins / genetics,  metabolism
Morphogenesis / physiology
Photoreceptor Cells, Invertebrate / cytology,  physiology
Signal Transduction
Reg. No./Substance:
0/Drosophila Proteins; 0/Eye Proteins

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