| Two successive ocular malignancies in the same eye of a HIV-positive patient: a case report. | |
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MedLine Citation:
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PMID: 20370336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report 2 successive ocular malignancies in the same eye of a HIV-positive patient at different CD4 counts. MATERIALS AND METHODS: A 36-year-old retrovirus-positive male presented with no perception of light in the left eye of 1 month duration. CD4 counts were 44 cells/mm(3). Ultrasonography showed an exudative retinal detachment. Retinal biopsy suggested an intraocular B-cell lymphoma for which he received radiotherapy and chemotherapy. He presented 3 years later with a growth in the left eye with CD4 counts of 360 cells/mm(3). RESULTS: Histopathology of enucleated eye showed a low-grade conjunctival squamous cell carcinoma. At 1-year follow-up, there is no mass in the anophthalmic socket. CONCLUSIONS: This case highlights the development of 2 ocular malignancies in the same eye of an HIV-positive patient, at different CD4 counts, allowing the authors to speculate on additional factors involved in the development of the second malignancy. |
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Authors:
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Kalpana Babu; Krishna R Murthy; Subramanian Krishnakumar |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 18 ISSN: 1744-5078 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: England |
Other Details:
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Languages: eng Pagination: 101-3 Citation Subset: IM |
Affiliation:
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Vittala International Institute of Ophthalmology & Prabha Eye Clinic and Research Center, Bangalore, India. kb_7375@yahoo.co.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / administration & dosage Blindness / drug therapy, etiology, pathology* CD4 Lymphocyte Count Carcinoma, Squamous Cell / drug therapy, immunology, pathology* Cyclophosphamide / administration & dosage Doxorubicin / administration & dosage Eye Enucleation / adverse effects Eye Neoplasms / drug therapy, immunology, pathology* HIV Infections / complications*, immunology Humans Lymphoma, B-Cell / drug therapy, immunology, pathology* Male Neoplasms, Second Primary / drug therapy, immunology, pathology* Prednisolone / administration & dosage Retinal Detachment / etiology, pathology Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 57-22-7/Vincristine |
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