Document Detail

Two successful pregnancies obtained following oocyte vitrification and embryo re-vitrification.
MedLine Citation:
PMID:  18339254     Owner:  NLM     Status:  MEDLINE    
Recent clinical reports not only show that cryopreserved embryos can be successfully used for human fertility treatment, but also that cryopreserved oocytes may be used successfully as an adjunct to human assisted reproductive technologies. Vitrification is known to establish a glass-like solid state during the cooling process. The high concentration of cryoprotectants and an extremely rapid rate of cooling are responsible for the formation of the solid state, and also prevent formation of intracellular ice crystals. Hence, in theory, vitrification should minimize cryo-injuries, and therefore has great promise for oocyte and embryo cryopreservation. This article describes two pregnancies from vitrified-warmed blastocysts obtained after intracytoplasmic sperm injection fertilization of vitrified-warmed oocytes. Vitrification was employed to cryopreserve the oocytes and the subsequent blastocysts. The results present the intriguing implication that vitrification may serve as an efficient method for clinical oocyte cryopreservation and embryo re-cryopreservation.
Ching-Chien Chang; Daniel B Shapiro; Diana Patricia Bernal; Graham Wright; Hilton I Kort; Zsolt Peter Nagy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  16     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-14     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  IM    
Reproductive Biology Associates, 1150 Lake Hearn Drive, Suite 600, Atlanta, GA 30342, USA.
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MeSH Terms
Cryopreservation / methods*
Sperm Injections, Intracytoplasmic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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