Document Detail

Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency.
MedLine Citation:
PMID:  16244492     Owner:  NLM     Status:  MEDLINE    
Inherited thrombophilias are associated with an increased risk of maternal thromboembolism and certain adverse pregnancy outcomes, including second- and third-trimester fetal loss, placental abruption, severe intrauterine growth restriction, and early-onset, severe preeclampsia. Pregnant patients with severe thrombophilias, especially antithrombinopathies are at very high risk for both thromboembolism and adverse pregnancy outcomes. A case of a patient with antithrombin deficiency is reported, who had two successful pregnancies after eight miscarriages. Our case shows that a combined treatment with antithrombin substitution and a prophylactic, body-weight-adjusted dose of low-molecular-weight heparin may be successful in preventing pregnancy loss and thromboembolism in antithrombin deficiency during pregnancy, although other complications, such as preeclampsia and intrauterine growth restriction cannot always be prevented.
A Szilágyi; A Nagy; P Tamás; M Vizer; I Szabó; H Losonczy
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-10-21
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  61     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-21     Completed Date:  2007-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, University of Pécs, Pécs, Hungary.
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MeSH Terms
Abortion, Habitual / prevention & control*
Anticoagulants / therapeutic use*
Fibrin / deficiency*
Heparin / therapeutic use*
Infertility, Female / etiology,  therapy
Pregnancy Complications, Hematologic / genetics*
Thromboembolism / genetics
Thrombophilia / genetics
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 9001-31-4/Fibrin; 9005-49-6/Heparin

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