Document Detail


Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency.
MedLine Citation:
PMID:  16244492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inherited thrombophilias are associated with an increased risk of maternal thromboembolism and certain adverse pregnancy outcomes, including second- and third-trimester fetal loss, placental abruption, severe intrauterine growth restriction, and early-onset, severe preeclampsia. Pregnant patients with severe thrombophilias, especially antithrombinopathies are at very high risk for both thromboembolism and adverse pregnancy outcomes. A case of a patient with antithrombin deficiency is reported, who had two successful pregnancies after eight miscarriages. Our case shows that a combined treatment with antithrombin substitution and a prophylactic, body-weight-adjusted dose of low-molecular-weight heparin may be successful in preventing pregnancy loss and thromboembolism in antithrombin deficiency during pregnancy, although other complications, such as preeclampsia and intrauterine growth restriction cannot always be prevented.
Authors:
A Szilágyi; A Nagy; P Tamás; M Vizer; I Szabó; H Losonczy
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-10-21
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  61     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-21     Completed Date:  2007-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics and Gynecology, University of Pécs, Pécs, Hungary. andras.szilagyi@aok.pte.hu
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / prevention & control*
Adult
Anticoagulants / therapeutic use*
Female
Fibrin / deficiency*
Heparin / therapeutic use*
Humans
Infertility, Female / etiology,  therapy
Pregnancy
Pregnancy Complications, Hematologic / genetics*
Thromboembolism / genetics
Thrombophilia / genetics
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticoagulants; 9001-31-4/Fibrin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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