| Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. | |
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MedLine Citation:
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PMID: 18603535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cryopreservation of the ovarian cortex with subsequent autotransplantation has, on an experimental basis, been performed to preserve fertility in women being treated for a malignant disease. The present study reports ovarian activity and pregnancies following autotransplantation of frozen/thawed ovarian tissue. METHODS: One complete ovary was cryopreserved from each of six patients who were 26-35 years old prior to treatment. Tissue from three of the patients was transported 4-5 h on ice prior to cryopreservation. After a period of 17-32 months, orthotopic autotransplantation was performed replacing 20-60% of the tissue. Two patients received additional heterotopic transplants. RESULTS: In all cases, the tissue restored menstrual cyclicity 14-20 weeks following transplantation. Four of the six women conceived following assisted reproduction: two women (who had the tissue transported 4-5 h prior to cryopreservation) each, based on the orthotopic transplanted tissue, delivered one healthy child (February 2007 and January 2008); one woman miscarriaged in gestational Week 7; and the other had a positive hCG test but no clinical pregnancy. The remaining two women did not become pregnant. CONCLUSIONS: Two additional healthy children have been born as a result of the ovarian cryopreservation procedure. In both cases, the ovarian tissue was transported 4-5 h prior to freezing demonstrating that hospitals may offer cryopreservation without having the necessary expertise locally. |
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Authors:
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Claus Yding Andersen; Mikkel Rosendahl; Anne Grete Byskov; Anne Loft; Christian Ottosen; Margit Dueholm; Kirsten L T Schmidt; Anders Nyboe Andersen; Erik Ernst |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-03 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 23 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-18 Completed Date: 2009-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2266-72 Citation Subset: IM |
Affiliation:
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Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark. yding@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cryopreservation Female Humans Infertility / prevention & control Menstrual Cycle / physiology Ovary / physiology, transplantation* Pregnancy Pregnancy Outcome Reproductive Techniques, Assisted Transplantation, Autologous |
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