Document Detail

Two successful pregnancies after in vitro fertilization and embryo transfer in a patient with endometrial atypical hyperplasia bordering on adenocarcinoma treated conservatively with high-dose progesterone.
MedLine Citation:
PMID:  16131806     Owner:  NLM     Status:  MEDLINE    
Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable.
Benjamin Piura
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-08-30
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  61     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-10     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  21-3     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Soroka Medical Center and Faculty of Health Sciences, Cancer Research Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
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MeSH Terms
Adenocarcinoma / drug therapy*
Anovulation / complications
Embryo Transfer*
Endometrial Hyperplasia / drug therapy*
Fertilization in Vitro*
Infertility, Female / etiology
Progesterone / administration & dosage,  therapeutic use*
Treatment Outcome
Uterine Neoplasms / drug therapy*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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