Document Detail


Two successful pregnancies after in vitro fertilization and embryo transfer in a patient with endometrial atypical hyperplasia bordering on adenocarcinoma treated conservatively with high-dose progesterone.
MedLine Citation:
PMID:  16131806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable.
Authors:
Benjamin Piura
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-08-30
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  61     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-10     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  21-3     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Soroka Medical Center and Faculty of Health Sciences, Cancer Research Center, Ben Gurion University of the Negev, Beer-Sheva, Israel. piura@bgumail.bgu.ac.il
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy*
Adult
Anovulation / complications
Embryo Transfer*
Endometrial Hyperplasia / drug therapy*
Female
Fertilization in Vitro*
Humans
Infertility, Female / etiology
Pregnancy
Progesterone / administration & dosage,  therapeutic use*
Treatment Outcome
Uterine Neoplasms / drug therapy*
Chemical
Reg. No./Substance:
57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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