Document Detail

Two subpopulations of patients with early and late onset of psoriasis differ regarding alpha 1-proteinase inhibitor activity.
MedLine Citation:
PMID:  2609895     Owner:  NLM     Status:  MEDLINE    
Two subpopulations of patients with psoriasis were identified when activity of alpha 1-proteinase inhibitor was analysed according to the patient's age at onset of the disease. Patients with early onset had more active lesions, high incidence of familial psoriasis, and reduced alpha 1-proteinase inhibitor during flare similar to that activity in remission. In contrast, alpha 1-proteinase activity increased significantly during flare in patients with late onset (above 21 yrs of age) in response to the inflammatory process in the psoriatic skin.
W Glinski; D Barszcz; M Glinska-Ferenz; Z Zarebska; S Jablonska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica. Supplementum     Volume:  146     ISSN:  0365-8341     ISO Abbreviation:  Acta Derm Venereol Suppl (Stockh)     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-21     Completed Date:  1990-02-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370311     Medline TA:  Acta Derm Venereol Suppl (Stockh)     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Department of Dermatology, Academy of Medicine, Warsaw, Poland.
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MeSH Terms
Age Factors
Aged, 80 and over
Keratinocytes / cytology
Middle Aged
Neutrophils / enzymology
Psoriasis / enzymology*,  genetics,  pathology
alpha 1-Antitrypsin / analysis,  biosynthesis,  metabolism*
Reg. No./Substance:
0/alpha 1-Antitrypsin

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