| Two-stage transvaginal cervical length screening for preterm birth in twin pregnancies. | |
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MedLine Citation:
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PMID: 20629488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To compare cervical length (CL) at 18-21 and 22-25 weeks' gestation in twin pregnancies in prediction of spontaneous preterm delivery and to examine cervical shortening. METHODS: Retrospective cohort study of CL measured at 18-21 and 22-25 weeks' gestation in twin pregnancies. RESULTS: Receiver operating characteristics (ROC) curve revealed area of 0.64 (95% CI 0.53-0.75) and 0.80 (95% CI 0.72-0.88) for measurements at 18-21 and 22-25 weeks, respectively (P<or=0.001). Sensitivities of 33.3% and 23% and negative predicting value (NPV) of 97.3% and 86.8% for delivery at <28 and <34 weeks gestation were reached for measurements at 18-21 weeks. Sensitivities of 71.4% and 38.2% and NPV of 99.1% and 91.4% for delivery at <28 and <34 weeks' gestation were reached for measurements at 22-25 weeks. Cervical length shortening analysis showed an area under ROC curve of 0.81 (95% CI 0.73-0.89) and best cut-off was at >or=2 mm/week. Sensitivities of 80% and 60.8% and NPV of 98.9% and 90.6% for delivery at <28 and <34 weeks gestation were reached. CONCLUSIONS: In twin gestations, assessment of CL at 22-25 weeks is better than assessment at 18-21 weeks to predict preterm delivery before 34 weeks. Cervical shortening at a rate of >or=2 mm/weeks between 18 and 25 weeks gestation was a good predictor of spontaneous preterm birth in this high-risk population. |
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Authors:
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Carolina Hofmeister; Maria de Lourdes Brizot; Adolfo Liao; Rossana P V Francisco; Marcelo Zugaib |
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Publication Detail:
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Type: Journal Article; Twin Study |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 38 ISSN: 1619-3997 ISO Abbreviation: J Perinat Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 479-84 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil. hofcarol@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cervical Length Measurement*
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statistics & numerical data Cervix Uteri / ultrasonography Cohort Studies Female Gestational Age Humans Infant, Newborn Male Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Pregnancy, Multiple* Premature Birth / etiology, ultrasonography* Retrospective Studies Risk Factors Twins* |
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