Document Detail

Two-stage revision of infected total knee replacements using articulating cement spacers and short-term antibiotic therapy.
MedLine Citation:
PMID:  16877598     Owner:  NLM     Status:  MEDLINE    
We present a series of 48 patients with infected total knee replacements managed by the use of articulating cement spacers and short-term parenteral antibiotic therapy in the postoperative period. All patients had microbiological and/or histological confirmation of infection at the first stage of their revision. They all underwent re-implantation and had a mean follow-up of 48.5 months (26 to 85). Infection was successfully eradicated in 42 of the 48 patients (88%). Six had persistent infection which led to recurrence of symptoms and further surgery was successful in eliminating infection in four patients. These rates of success are similar to those of other comparable series. We conclude that protracted courses of intravenous antibiotic treatment may not be necessary in the management of the infected total knee replacement. In addition, we analysed the microbiological, histological and serological results obtained at the time of re-implantation of the definitive prosthesis, but could not identify a single test which alone would accurately predict a successful outcome.
W J Hart; R S Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  88     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-25     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  1011-5     Citation Subset:  AIM; IM    
The Robert Jones and Agnes Hunt Orthopaedic and District Hospital, Oswestry, Shropshire SY10 7AG, UK.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Arthroplasty, Replacement, Knee*
Bone Cements*
Gentamicins / therapeutic use
Knee Joint / physiopathology,  surgery
Knee Prosthesis
Middle Aged
Predictive Value of Tests
Prosthesis-Related Infections / drug therapy,  microbiology,  surgery*
Range of Motion, Articular / physiology
Retrospective Studies
Treatment Outcome
Vancomycin / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bone Cements; 0/Gentamicins; 1404-90-6/Vancomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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