Document Detail

Two specific markers for neural differentiation of embryonal carcinoma cells.
MedLine Citation:
PMID:  11892798     Owner:  NLM     Status:  MEDLINE    
Two multipotential embryonal carcinoma (EC) cell lines, 1003 and 1009, can be induced to form preferentially neural derivatives in vitro. Synthesis of specific proteins during neural differentiation was followed by two-dimensional gel electrophoresis. The comparison of protein patterns obtained with neural and non-neural derivatives of these EC cell lines indicates that two changes are specific for the neural pathway: (i) the appearance of a new beta-tubulin isoform and (ii) the accumulation of the brain isozyme of creatine phosphokinase already present in small amounts in EC stem cells. These changes were found to take place early in the course of differentiation and to occur even when neurite outgrowth was prevented.
B Eddé; H Jakob; M Darmon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  2     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  1983  
Date Detail:
Created Date:  2002-03-14     Completed Date:  2002-04-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1473-8     Citation Subset:  IM    
Service de Génétique cellulaire du Collège de France et de l'Institut Pasteur, Paris.
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MeSH Terms
Carcinoma, Embryonal / metabolism*,  pathology*
Cell Differentiation
Creatine Kinase / metabolism*
Creatine Kinase, BB Form
Heat-Shock Proteins / metabolism
Isoenzymes / metabolism*
Neurons / metabolism,  pathology
Tubulin / metabolism*
Tumor Cells, Cultured
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Heat-Shock Proteins; 0/Isoenzymes; 0/Tubulin; 0/Tumor Markers, Biological; EC Kinase; EC Kinase, BB Form

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