Document Detail


Two sites for modulation of human sympathetic activity by arterial baroreceptors?
MedLine Citation:
PMID:  11251065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Peroneal muscle sympathetic nerve activity (MSA), finger blood pressure and cardiac intervals were recorded at rest in 60 healthy subjects, aged 18-71 years. Arterial baroreflex control of MSA was analysed by relating each spontaneous sympathetic burst to the diastolic blood pressure and the cardiac interval of the heart beat during which the burst was generated. The results were expressed as blood pressure/cardiac interval threshold for occurrence of bursts, and as baroreflex sensitivity (i.e. the relationship between diastolic pressure/cardiac interval and burst strength). 2. Significant blood pressure/cardiac interval thresholds were present in all subjects and old subjects had less variability of thresholds than young subjects. In contrast, significant baroreflex sensitivity for diastolic pressure and cardiac interval was present in only 55 and 73 % of the subjects, respectively. There was no age-related difference in sensitivity. 3. In 40 subjects, two 5 min periods from the same recording were analysed. The number of sympathetic bursts and the threshold for occurrence of bursts were reproducible in all subjects. In contrast, significant baroreflex sensitivity in both periods was present in only 30 % (diastolic pressure) and 40 % (cardiac interval) of the subjects. 4. The results show that the baroreflex mechanisms regulating the occurrence and strength of sympathetic bursts are not identical. We suggest that the modulation occurs at two sites, one which determines whether or not a burst will occur, and another at which the strength of the discharge is determined.
Authors:
P Kienbaum; T Karlssonn; Y B Sverrisdottir; M Elam; B G Wallin
Related Documents :
19926535 - Peripheral chemoreflex sensitivity and sympathetic nerve activity are normal in apnea d...
8214105 - Localization of central pressor action of bradykinin in medulla oblongata.
3121155 - Central and peripheral mechanisms of arterial pressure lability following baroreceptor ...
23059865 - Soccer improves fitness and attenuates cardiovascular risk factors in hypertensive men.
16552245 - Measuring intraocular pressure-adjustments for corneal thickness and new technologies.
17982005 - Coronary effluent from a preconditioned heart activates the jak-stat pathway and induce...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  531     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-19     Completed Date:  2001-05-17     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  861-9     Citation Subset:  IM    
Affiliation:
Institute of Clinical Neuroscience, Unit of Clinical Neurophysiology, Sahlgren Hospital, University of Göteborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arteries / innervation*
Baroreflex / physiology
Blood Pressure / physiology
Diastole
Differential Threshold
Female
Fingers / blood supply
Heart Rate / physiology
Humans
Male
Middle Aged
Muscle, Skeletal / innervation
Pressoreceptors / physiology*
Reproducibility of Results
Sympathetic Nervous System / physiology*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Interhemispheric facilitation of the hand motor area in humans.
Next Document:  Sarcoplasmic reticulum function and muscle contractile character following fatiguing exercise in hum...