| Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. | |
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MedLine Citation:
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PMID: 1886719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Analysis of several cases of t(1:14)(p32;q11) translocation present in 3% of T-cell acute leukemias (T-ALL) has revealed the tal-1 gene. This gene encodes a helix-loop-helix protein. It has been found to be expressed in normal bone marrow and in leukemic T-cell and erythroleukemia cell lines, but not in normal T cells. Recently, a site-specific deletion, tald, renamed tald1 in this paper, has been detected in a high proportion of pediatric T-ALL, which arose by a site-specific DNA recombination between tal-1 and a new locus termed SIL. In this study we searched for structural rearrangements within tal-1 in a panel of 134 non-selected leukemic patients (including 66 with T-ALL). Only 6% of patients with T-ALL harbored the tald1 deletion. A second specific deletion termed tald2 was observed in another 6% of T-ALL patients; it involves another site within tal-1 plus the same site as tald1 in the SIL locus. Similarly to tald1 deletion, tald2 junctions harbor structural characteristics that are reminiscent of aberrant recombinase activity. Moreover, we report a detailed analysis of the tal-1 gene structure. Transcription analysis and in vitro translation data are consistent with the differential expression of several TAL-1 protein species containing the HLH motif but differing in their amino terminus. Taken together, our data indicate that t(1;14) translocations and both tald deletions disrupt the 5' part of the tal-1 gene, placing its entire coding sequences under the control of the regulatory elements of the TCR-delta gene or the SIL gene, both of which are normally expressed in T-cell lineage. |
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Authors:
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O Bernard; N Lecointe; P Jonveaux; M Souyri; M Mauchauffé; R Berger; C J Larsen; D Mathieu-Mahul |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncogene Volume: 6 ISSN: 0950-9232 ISO Abbreviation: Oncogene Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-10-04 Completed Date: 1991-10-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1477-88 Citation Subset: IM |
Affiliation:
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INSERM U301, Institut de Génétique Moléculaire, Paris, France. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/S53245; S53678; S53686; S53691; S53698; S74831; S74923; S74924; S74925; S74926 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Bone Marrow / metabolism, pathology, ultrastructure Chromosome Deletion* Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 14 DNA, Neoplasm / genetics, isolation & purification Genes, Regulator / genetics Humans Leukemia-Lymphoma, Adult T-Cell / genetics*, metabolism, pathology Molecular Sequence Data Molecular Structure Promoter Regions, Genetic / genetics Protein Biosynthesis / genetics Receptors, Antigen, T-Cell / genetics, metabolism Transcription, Genetic / genetics Translocation, Genetic / genetics* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Receptors, Antigen, T-Cell |
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