Document Detail

Two siblings with lichen planus and squamous cell carcinoma of the oesophagus.
MedLine Citation:
PMID:  16957518     Owner:  NLM     Status:  MEDLINE    
Lichen planus is a mucocutaneous disease which can also affect the oesophagus. Unlike in oral lichen planus an increased risk for the development of squamous cell carcinoma in the oesophagus has not been established. We describe two sisters with a history of long-standing cutaneous lichen planus who developed oesophageal squamous cell carcinoma, diagnosed at the ages of 68 and 70 years, respectively. In one of the cases, dysplastic areas were identified by high-magnification chromoendoscopy. In both cases, oesophageal resection was carried out with a curative intent. For the first time these sibling case reports suggest an increased precancerous potential of oesophageal lichen planus.
Matthijs P Schwartz; Vigfus Sigurdsson; Willem Vreuls; Pieter H W Lubbert; André J P M Smout
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  18     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-07     Completed Date:  2007-09-27     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1111-5     Citation Subset:  IM    
Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands.
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MeSH Terms
Carcinoma, Squamous Cell / genetics,  pathology*
Esophageal Diseases / genetics,  pathology*
Esophageal Neoplasms / genetics,  pathology
Lichen Planus / genetics,  pathology*
Precancerous Conditions / genetics,  pathology*
Comment In:
Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1043-5   [PMID:  16957508 ]

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