| Two sensitive echocardiographic techniques for detecting doxorubicin toxicity. | |
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MedLine Citation:
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PMID: 6855698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This investigation was designed to evaluate echoes of patients who received a course of doxorubicin (225-550 mg/m2) by two sensitive indicators of myocardial fibrosis: (1) M-mode scans of thickening-thinning curves of the left ventricular posterior wall (LVPW), and (2) two-dimensional qualitative evaluation of LVPW contraction at three levels of the LV short axis (leaflet, chordal, and papillary). These were compared to standard M-mode shortening fraction (delta S). Eighteen children with cancer were evaluated; 11 had received doxorubicin and 7 were treated with other agents. Echocardiographers were unaware of the treatment category. All controls and 10 of 11 doxorubicin patients had normal delta S. An M-mode echocardiogram of the expanded LVPW was digitized and wall thickness was evaluated by determining if diastolic relaxation had the normal two phases or only one; six of ten doxorubicin patients and no controls had abnormal relaxation. Qualitative evaluation of LVPW and septal contraction toward the center of the ventricle showed that seven of eleven patients who received doxorubicin and one control (a postthoracotomy patient) had contraction deficits. Six of seven with contraction deficit were the same patients with slowed relaxation. The greatest contraction deficit occurred in the LVPW behind the posterior mitral leaflet. Patients with more extensive involvement had an additional contraction deficit extending to the apex. These tests are more sensitive for detection of doxorubicin toxicity than delta S. |
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Authors:
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S J Goldberg; J J Hutter; L Feldman; S M Goldberg |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Medical and pediatric oncology Volume: 11 ISSN: 0098-1532 ISO Abbreviation: Med. Pediatr. Oncol. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506654 Medline TA: Med Pediatr Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 172-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiomyopathies / chemically induced*, physiopathology Child Child, Preschool Doxorubicin / adverse effects* Echocardiography / methods* Heart / physiopathology Humans |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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