Document Detail


Two roads diverge: weight loss interventions and circulating amino acids.
MedLine Citation:
PMID:  21525396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this issue of Science Translational Medicine, Laferrère and colleagues describe a metabolite profiling approach to investigate changes in the circulating metabolome after equivalent weight loss spurred by either gastric bypass surgery (GBP) or dietary intervention. The results reveal that GBP enhances branched chain amino acid metabolism by mechanisms separate from weight loss. These observations raise the possibility that changes in circulating amino acids play a role in the correction of glycemic control observed shortly after GBP.
Authors:
Robert E Gerszten; Thomas J Wang
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science translational medicine     Volume:  3     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-28     Completed Date:  2011-10-19     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80ps15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 2 / diet therapy*,  metabolism*
Female
Gastric Bypass*
Humans
Male
Obesity / diet therapy*,  metabolism*
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
N01-HC-25195/HC/NHLBI NIH HHS; R01 DK081572/DK/NIDDK NIH HHS; R01-DK-HL081572/DK/NIDDK NIH HHS
Comments/Corrections
Comment On:
Sci Transl Med. 2011 Apr 27;3(80):80re2   [PMID:  21525399 ]
Erratum In:
Sci Transl Med. 2011 May 4;3(81):81er3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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