| Two rare complications of glioblastoma multiforme: persistent hiccup and acquired haemophilia A. | |
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MedLine Citation:
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PMID: 18663257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 69-year-old man was admitted to the hospital with persistent hiccups. Computed tomography and magnetic resonance imaging of the brain were performed and revealed a glioblastoma multiforme localised in the right temporal lobe. After resection, the hiccups disappeared, suggesting that temporal areas are involved in control mechanisms of hiccups. A month later, the patient was readmitted because of skin, mucosal and soft tissue bleedings. Laboratory findings showed a prolonged aPTT, a low factor VIII activity and a factor VIII inhibitor, leading to the diagnosis of acquired haemophilia A. Acquired haemophilia A is a potentially life-threatening haemorrhagic disorder resulting from the presence of antibodies against factor VIII. We believe that this disorder developed due to exposure of factor VIII(-like) tumour antigens to the immune system. This case illustrates two yet unknown complications of a glioblastoma multiforme: persistent hiccups and acquired haemophilia A. |
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Authors:
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C M P G van Durme; R N Idema; C van Guldener |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 66 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 286-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Amphia Hospital, Breda, the Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Neoplasms / complications*, diagnosis Diagnosis, Differential Factor VII / metabolism Glioblastoma / complications*, diagnosis Hemophilia A / blood, diagnosis, etiology* Hiccup / diagnosis, etiology* Humans Magnetic Resonance Imaging Male Temporal Lobe* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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9001-25-6/Factor VII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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