Document Detail

Two-pulse biexponential-weighted (23)Na imaging.
MedLine Citation:
PMID:  24530955     Owner:  NLM     Status:  Publisher    
A new method is proposed for acquiring 3D biexponential-weighted sodium images with two instead of three RF pulses to allow for shorter repetition time at high magnetic fields (B0⩾7T) and reduced SAR. The second pulse converts single- into triple-quantum coherences in regions containing sodium ions which are restricted in mobility. Since only single-quantum coherences can be detected, an image acquired after the second pulse is intrinsically single-quantum-filtered and can be used to generate a biexponential-weighted sodium image by a weighted subtraction with the spin-density-weighted image acquired between the pulses. The proposed sequence generates biexponential-weighted sodium images of in vivo human brain with 140% higher SNR than triple-quantum-filtered sodium images and 4% higher SNR than a biexponential-weighted sequence with three RF pulses at equal acquisition time and with 1/3 lower SAR. As SAR is reduced, accordingly repetition time can be spared to obtain even higher SNR-time efficiency. In comparison to a difference image generated from two images of a double-readout sequence, the proposed two-pulse sequence yields about 14% higher SNR. Our new two-pulse biexponential-weighted sequence allows for acquisition of full 3D data sets of the human brain in vivo with a nominal resolution of (5mm)(3) in about 10min.
Nadia Benkhedah; Peter Bachert; Armin M Nagel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-28
Journal Detail:
Title:  Journal of magnetic resonance (San Diego, Calif. : 1997)     Volume:  240C     ISSN:  1096-0856     ISO Abbreviation:  J. Magn. Reson.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707935     Medline TA:  J Magn Reson     Country:  -    
Other Details:
Languages:  ENG     Pagination:  67-76     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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