Document Detail

Two pharmacy interventions to improve refill persistence for chronic disease medications: a randomized, controlled trial.
MedLine Citation:
PMID:  19106728     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite the proven effectiveness of many medications for chronic diseases, many patients do not refill their prescriptions in the required timeframe. OBJECTIVE: Compare the effectiveness of 3 pharmacist strategies to decrease time to refill of prescriptions for common chronic diseases. RESEARCH DESIGN/SUBJECTS: A randomized, controlled clinical trial with patients as the unit of randomization. Nine pharmacies within a medium-sized grocery store chain in South Carolina were included, representing urban, suburban, and rural areas and patients from a variety of socioeconomic backgrounds. Patients (n = 3048) overdue for refills for selected medications were randomized into 1 of 3 treatment arms: (1) pharmacist contact with the patient via telephone, (2) pharmacist contact with the patient's prescribing physician via facsimile, and (3) usual care. MEASURES: The primary outcome was the number of days from their recommended refill date until the patient filled a prescription for any medication relevant to his/her chronic disease. Prescription refill data were obtained routinely from the pharmacy district office's centralized database. Patient disposition codes were obtained by pharmacy employees. An intent-to-treat approach was used for all analyses. RESULTS: There were no significant differences by treatment arm in the study outcomes. CONCLUSIONS: Neither of the interventions is more effective than usual care at improving persistence of prescription refills for chronic diseases in overdue patients.
Paul J Nietert; Barbara C Tilley; Wenle Zhao; Peter F Edwards; Andrea M Wessell; Patrick D Mauldin; Pam P Polk
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical care     Volume:  47     ISSN:  1537-1948     ISO Abbreviation:  Med Care     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0230027     Medline TA:  Med Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA.
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MeSH Terms
Chronic Disease / drug therapy*,  ethnology
Clinical Pharmacy Information Systems
Directive Counseling / utilization
Drug Utilization*
Insurance, Pharmaceutical Services
Medication Adherence / ethnology,  statistics & numerical data*
Middle Aged
Outcome Assessment (Health Care)
Pharmacies / organization & administration*
Program Evaluation
Proportional Hazards Models
Reminder Systems / classification*,  utilization
Socioeconomic Factors
South Carolina
Telefacsimile / utilization*
Telephone / utilization*
Time Factors
United States
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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