| Two new biphenanthrenes with cytotoxic activity from Bulbophyllum odoratissimum. | |
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MedLine Citation:
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PMID: 19446615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two new dimeric phenanthrenes, bulbophythrins A (1) and B (2), were isolated from Bulbophyllum odoratissimum. Their structures were elucidated by HR-ESI-MS, 1D and 2DNMR spectroscopy. They were evaluated in vitro for their inhibitory ability against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer SGC-7901. Both compounds showed significant cytotoxicity against the tested cell lines. Compound 1 exhibited some selectivity against HL-60 and BEL-7402 with IC(50) values of 1.27 x 10(-3) and 1.22 x 10(-3) micromol/ml respectively, whereas 2 was most active against A549 with IC(50) value of 1.18 x 10(-3) micromol/ml. |
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Authors:
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Junju Xu; Hong Yu; Chen Qing; Yanli Zhang; Ying Liu; Yegao Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-14 |
Journal Detail:
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Title: Fitoterapia Volume: 80 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 381-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Yunnan Normal University, Kunming 650092, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy Antineoplastic Agents, Phytogenic / isolation & purification, pharmacology*, therapeutic use Carcinoma, Hepatocellular / drug therapy Cell Line, Tumor Humans Neoplasms / drug therapy* Nuclear Magnetic Resonance, Biomolecular Orchidaceae* Phenanthrenes / isolation & purification, pharmacology*, therapeutic use Plant Extracts / chemistry, pharmacology*, therapeutic use Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Phenanthrenes; 0/Plant Extracts; 0/bulbophythrin A; 0/bulbophythrin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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