Document Detail


Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties.
MedLine Citation:
PMID:  20493687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.
Authors:
Alla A Kicha; Natalia V Ivanchina; Trinh T T Huong; Anatoly I Kalinovsky; Pavel S Dmitrenok; Sergey N Fedorov; Sergey A Dyshlovoy; Pham Q Long; Valentin A Stonik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-09
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3826-30     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / isolation & purification*
Cell Line, Tumor
Hela Cells
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
NF-kappa B / genetics
Saponins / isolation & purification,  pharmacology*
Starfish / chemistry*
Transcription Factor AP-1 / genetics
Transcriptional Activation / drug effects
Tumor Suppressor Protein p53 / genetics
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/NF-kappa B; 0/Saponins; 0/Transcription Factor AP-1; 0/Tumor Suppressor Protein p53; 0/archasteroside A; 0/archasteroside B; 0/regularoside A

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