| Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20021265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting. DESIGN: In a standardized, questionnaire-based interview, women selected from a control cohort for association studies were asked retrospectively about nausea and vomiting during their first pregnancy. POPULATION: A total of 593 women who had completed at least one pregnancy and for whom germline DNA was available were selected. METHODS: Eight SNPs in the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, and NK1R (TACR1) were tested using polymerase chain reaction. The occurrence of nausea and vomiting was correlated with the patients' genotyping results and medical history parameters. RESULTS: Both young age at first pregnancy and positive smoking status were significantly associated with vomiting and nausea during pregnancy. After adjustment for these two parameters, the two SNPs rs6806362 (odds ratio (OR) 1.38 per allele; 95% confidence interval (CI) 1.06-1.79; p = 0.017) and rs6807670 (OR 1.37; 95% CI 1.05-1.79 per allele; p = 0.023) were marginally associated with pregnancy-related nausea. None of the other polymorphisms showed any association. CONCLUSION: Polymorphisms in the subunit gene HTR3C of the serotonin receptor may be involved in the pathogenesis of pregnancy-associated nausea. |
| | |
Authors:
|
Tamme W Goecke; Arif B Ekici; Beate Niesler; Christian R Loehberg; Christian Hammer; Gudrun Rappold; Denny Schanze; Verica Straub; Hans-Harald Altmann; Pamela Strissel; Reiner Strick; Matthias W Beckmann; Peter A Fasching |
Related Documents
:
|
984145 - A new, more sensitive tube test for pregnancy evaluated with a selected hospital popula... 16945785 - Experience of taiwanese women living with nausea and vomiting during pregnancy. 6234945 - Dynamic fetoplacental unit function test with dehydroepiandrosterone sulfate. 19589475 - Utilization of home pregnancy testing among women at risk for unintended pregnancy. 22432115 - Insulin requirements in type 1 diabetic pregnancy: do twin pregnant women require twice... 19646565 - Emergency contraceptive use as a marker of future risky sex, pregnancy, and sexually tr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 |
Date Detail:
|
Created Date: 2009-12-21 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
|
Languages: eng Pagination: 7-14 Citation Subset: IM |
Affiliation:
|
Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Female Genetic Variation* Humans Nausea / genetics* Odds Ratio Polymorphism, Single Nucleotide* Pregnancy Pregnancy Complications / genetics* Receptors, Serotonin, 5-HT3 / genetics* Receptors, Tachykinin / genetics Retrospective Studies Smoking / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/HTR3A protein, human; 0/HTR3B protein, human; 0/HTR3C protein, human; 0/HTR3D protein, human; 0/HTR3E protein, human; 0/Receptors, Serotonin, 5-HT3; 0/Receptors, Tachykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predicting the Determinants of Users' Intentions for Using YouTube to Share Video: Moderating Gender...
Next Document: Cervical tissue changes in women with miscarriage: A morphological and biochemical investigation.