Document Detail


Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.
MedLine Citation:
PMID:  20021265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting. DESIGN: In a standardized, questionnaire-based interview, women selected from a control cohort for association studies were asked retrospectively about nausea and vomiting during their first pregnancy. POPULATION: A total of 593 women who had completed at least one pregnancy and for whom germline DNA was available were selected. METHODS: Eight SNPs in the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, and NK1R (TACR1) were tested using polymerase chain reaction. The occurrence of nausea and vomiting was correlated with the patients' genotyping results and medical history parameters. RESULTS: Both young age at first pregnancy and positive smoking status were significantly associated with vomiting and nausea during pregnancy. After adjustment for these two parameters, the two SNPs rs6806362 (odds ratio (OR) 1.38 per allele; 95% confidence interval (CI) 1.06-1.79; p = 0.017) and rs6807670 (OR 1.37; 95% CI 1.05-1.79 per allele; p = 0.023) were marginally associated with pregnancy-related nausea. None of the other polymorphisms showed any association. CONCLUSION: Polymorphisms in the subunit gene HTR3C of the serotonin receptor may be involved in the pathogenesis of pregnancy-associated nausea.
Authors:
Tamme W Goecke; Arif B Ekici; Beate Niesler; Christian R Loehberg; Christian Hammer; Gudrun Rappold; Denny Schanze; Verica Straub; Hans-Harald Altmann; Pamela Strissel; Reiner Strick; Matthias W Beckmann; Peter A Fasching
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
Affiliation:
Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Female
Genetic Variation*
Humans
Nausea / genetics*
Odds Ratio
Polymorphism, Single Nucleotide*
Pregnancy
Pregnancy Complications / genetics*
Receptors, Serotonin, 5-HT3 / genetics*
Receptors, Tachykinin / genetics
Retrospective Studies
Smoking / epidemiology
Young Adult
Chemical
Reg. No./Substance:
0/HTR3A protein, human; 0/HTR3B protein, human; 0/HTR3C protein, human; 0/HTR3D protein, human; 0/HTR3E protein, human; 0/Receptors, Serotonin, 5-HT3; 0/Receptors, Tachykinin

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